FIGURE 6.

Effects of siRNA RAGE on DTH clinical score in WT and ALCAM^−/− mice, and effect of ALCAM^−/− RAGE^−/− double knockout on DTH clinical score. The time point is 24 h after DTH induction. (A) Mean clinical inflammation score in left footpads of WT mice with and without prior siRAGE treatment and of ALCAM^−/− mice with prior siRAGE treatment. Number of animals per group is indicated (n). (B) Mean clinical inflammation score in WT, ALCAM^−/−, RAGE^−/−, and ALCAM^−/− RAGE^−/− DKO mice with number of animals per group as indicated (n). Control animals of all groups without DTH showed no inflammation (clinical score = 1). Data for clinical inflammation score are the mean ± SE from two independent experiments in (A) and (B) each, with a total number of animals per group as indicated (n). *p < 0.02, **p = 0.015, ***p < 0.045.