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. 2013 Jun 3;191(1):145–153. doi: 10.4049/jimmunol.1203165

FIGURE 2.

FIGURE 2.

Gene signatures of maternal Treg cells during pregnancy indicate the involvement of IL-10 signaling pathway. (A) Representative density plots of sorting purities of Treg and non-Treg cells in nonpregnant and pregnant samples. Scatter plots of global gene expression comparing Treg and non-Treg cells in both study groups, followed by a Venn diagram showing the number of differentially expressed genes between Treg and non-Treg cells in nonpregnant (red circle) and pregnant (blue circle) women. A distinct subset of 93 genes is both Treg cell and pregnancy specific. These 93 genes were subjected to pathway analysis, where threshold of determining significant gene sets is <0.005. The IL-10 signaling pathway was the most significant immune response pathway. (B) PCA was performed on the 93 genes. This showed separations between nonpregnant and pregnant groups (principal component 1 [PC1]). Separation was also observed between non-Treg and Treg cells (principal component 2 [PC2]).