Invalid trials were associated with widespread bilateral activity in several regions including (Panel A) pre-supplementary/supplementary motor area (Pre-SMA/SMA), frontal eye fields (FEF), dorsolateral prefrontal cortex (DLPFC), and posterior parietal lobe (PPL). The left ventrolateral prefrontal cortex (VLPFC) was also active during invalidly cued trials. Slice locations (X and Z) are presented according to the Talairach atlas, and activations were color-coded (red versus yellow) according to p-value magnitude. Percent signal change (PSC) data is presented in Panel B for valid (VD; red bars) and invalid (IN; blue bars) trials for selected left (L), right (R) and bilateral (B) regions, with error bars equivalent to two times the standard error of the mean.