Table 3.

Single nucleotide polymorphisms associated with acute kidney injury.^a

							Discovery Set a		Validation Set a
SNP	Chr	Position	Gene	Alleleb	Location	MAFc	ORd (95% CI)	P-value	ORd (95% CI)	P-value
rs625145	11	116233146	SIK3	A/T	Intron	0.26/0.19	1.64 (1.19-2.28)	0.0028	1.52 (1.04-2.22)	0.029
rs2093266	14	94102540	SERPINA4	G/A	Intron	0.07/0.13	0.53 (0.34-0.82)	0.0042	0.55 (0.32-0.95)	0.031
rs1955656	14	94115128	SERPINA5	G/A	5′ UTR	0.07/0.13	0.52 (0.33-0.81)	0.0037	0.57 (0.33-0.97)	0.037
rs8094315	18	59087027	BCL2	A/G	Intron	0.17/0.25	0.62 (0.45-0.85)	0.0032	0.61 (0.41-0.91)	0.016
rs12457893	18	59077141	BCL2	A/C	Intron	0.42/0.51	0.68 (0.52-0.88)	0.0034	0.71 (0.53-0.96)	0.026

Definition of abbreviations: SNP=single nucleotide polymorphism; Chr=chromosome; MAF=minor allele frequency; OR=odds ratio; CI=confidence interval; UTR=untranslated region; BCL2=B-cell CLL/lymphoma 2 gene; SIK3=salt-inducible kinase family 3 gene; SERPINA4= serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 gene; SERPINA5= serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 gene; APACHE=Acute Physiology and Chronic Health Evaluation.

^aAdjusted for age, gender, and APACHE III score.

^bMajor allele / minor allele.

^cCases/controls.

^dOdds ratios are for each additional copy of the minor allele.