. Author manuscript; available in PMC: 2013 Jul 1.

Published in final edited form as: Crit Care Med. 2012 Jul;40(7):2116–2123. doi: 10.1097/CCM.0b013e3182514bca

Table 4.

Adjusted odds ratios and 95% confidence intervals for single nucleotide polymorphisms associated with acute kidney injury.^a

SNP	Gene	OR (Model 1) ^b	P-value (Model 1) ^b	OR (Model 2) ^c	P-value (Model 2) ^c
rs625145	SIK3	1.59 (1.24-2.03)	0.0002	1.56 (1.21-2.02)	0.0006
rs2093266	SERPINA4	0.54 (0.38-0.76)	0.0003	0.54 (0.38-0.76)	0.0005
rs1955656	SERPINA5	0.54 (0.38-0.76)	0.0004	0.54 (0.38-0.76)	0.0005
rs8094315	BCL2	0.61 (0.48-0.79)	0.0001	0.61 (0.47-0.79)	0.0002
rs12457893	BCL2	0.69 (0.57-0.84)	0.0002	0.67 (0.55-0.83)	0.0002

Definition of abbreviations: SNP=single nucleotide polymorphism; OR=odds ratio; CI=confidence interval; BCL2=B-cell CLL/lymphoma 2 gene; SIK3=salt-inducible kinase family 3 gene; SERPINA4= serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 gene; SERPINA5= serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 gene; APACHE=Acute Physiology and Chronic Health Evaluation.

Odds ratios are based on the entire cohort as a whole and represent the risk per each additional copy of the minor allele.

Model 1 adjusts for age, gender, and APACHE III score.

Model 2 adjusts for APACHE III score, platelet count, body mass index, location, source of infection, nosocomial source of infection, and need for vasopressors for greater than 48 hours.