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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Mol Cell Endocrinol. 2012 Dec 23;371(0):189–194. doi: 10.1016/j.mce.2012.12.011

Figure 3.

Figure 3

Anti-tumor effects of peptide analogs targeting LHRHR and GHRHR in MTT cells. AN-152 (10−6–10−7 mol/l) highly significant reduced MTT cell viability (A) and induced cell apoptosis (B) over 24–72h. (C) MIA-602 (10−5 mol/l) significantly reduced cell viability of more malignant MTT cells (48–72h). (D) Ultrastructural analyses. Confirmation of pro-apoptotic mode of cell death induced by AN-152, including shrinking of the cytoplasm away from the plasma membrane, apoptotic bodies, internucleosomal DNA fragmentation, or condensation of the cytoplasm while retaining mitochondria and endomembrane structure (Scale bar, 0.2 µm); DCV, dense-core vesicles; MIT, mitochondria; Nuc, nucleus.