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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Lancet Neurol. 2013 Feb;12(2):195–206. doi: 10.1016/S1474-4422(12)70309-5

Table 2.

Post-translational histone modifications associated with transcriptional repression

Histone modification Residues modified Enzymes
Wang et al (2008);24 Kouzarides (2007)25 Lysine deacetylation H2AK5, H2AK9, H2BK5, H2BK12, H2BK15, H2BK20, H2BK120, H3K4, H3K9, H3K14, H3K18, H3K23, H3K27, H3K36, H3K56, H4K5, H4K8, H4K12, H4K16, H4K91 HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC7, HDAC8, HDAC9, HDAC11, SIRT1, SIRT2, SIRT6, SIRT7
Greer and Shi (2012)26 Lysine methylation H3K9, K3K27, H4K20 EHMT1, EHMT2, EZH2, PRDM2, SETD8, SETDB1, SUV39H1, SUV39H2, SUV420H1, SUV420H2
Kooistra and Helin (2012)27 Lysine demethylation H3K4, H3K36 KDM1A, KDM1B, KDM2A, KDM2B, KDM4A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C, KDM5D, KDM8
Di Lorenzo and Bedford (2011)28 Arginine methylation H2AR3, H3R2, H3R8, H4R3 PRMT5, PRMT6, PRMT7
Thompson and Fast (2006)34 Arginine citrullination H3R2, H3R8, H3R17, H4R3 PADI4
Banerjee and Chakravarti (2011)30 Serine phosphorylation H2AS1 RPS6KA5
Shiio and Eisenman (2003)35 Lysine sumoylation Specific residues not yet determined UBE2I
Wang et al (2004)36 Lysine ubiquitylation H2AK119 RNF2