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. 2013 Jun 24;3:2053. doi: 10.1038/srep02053

Figure 2. Reverse correlation between Aβ plaques and vessel density.

Figure 2

(A) Correlation of the total vessel number in the brain cortex with size and number of Aβ40 or Aβ42 plaques. Brain samples from totally 15 AD patients and 12 non-AD individuals were used for correlation. (B) Double immunostaining of the cortex from an AD patient or from healthy control patients with an anti-CD31 (green) and TUNEL staining (red). Arrows indicate the vasculature-associated double positive apoptotic cells. Bar = 200 μm. (C) Quantification of CD31+ vessel-associated apoptotic index (n = 12–15 samples/group). (D) Quantification of the total number of CD31+ vessels in the cortex (n = 12–15 samples/group). * p < 0.05.