Figure 7.

Model for the role of BicD CC3 in orchestrating recruitment of cargo to dynein. See the text for details. Dimeric BicD is depicted. Note that it is currently not clear which features of BicD participate in the autoinhibitory binding and how this interaction is overcome by cargo association. (Bottom panel) It is also not known whether the proposed release of autoinhibition following cargo binding can also be stimulated by external regulators and/or interactions of the dynein complex with CC1/2. Dynactin is not shown for simplicity. Not to scale.