Table 1.
Disease course for New Zealand white rabbits pretreated with saline or LPS and then challenged with aerosolized B. anthracis spores
| Saline | LPS | ||
| LD50 | |||
| Mean | 246.5 ± 33.4 | 293.7 ± 19.7 | |
| Range | 127.7–445.5 | 207.8–380 | |
| Occurrence of anthrax-induced pyrexiaa | |||
| Mean | 24.8 ± 1.5 | 66.3 ± 12.1b | |
| Range | 15.8–29.8 | 34.8–130.5 | |
| Occurrence of bacteremiaa | |||
| Mean | 25.9 ± 2.0 | 62.5 ± 11.8b | |
| Range | 15.0–39.0 | 37.5–123 | |
| Length of survivala | |||
| Mean | 40.5 ± 2.6 | 89.6 ± 13.6b | |
| Range | 31.3–56.3 | 43.8–162.5 |
Rabbits were pretreated with saline or LPS (60,000 EU/kg) and then challenged 24 h later with approximately 300 LD50 aerosolized B. anthracis spores.
a
Time (h) after B. anthracis challenge.
b
Value significantly (P < 0.004) different from that of saline-pretreated, B. anthracis-challenged rabbits.