. Author manuscript; available in PMC: 2013 Jun 24.

Published in final edited form as: J Nucl Med. 2009 Nov 12;50(12):1954–1961. doi: 10.2967/jnumed.109.063289

TABLE 1.

Outcome Parameters of the 2T4K Model

Parameter	Before tariquidar	After tariquidar^*
K₁ (mL·mL⁻¹·min⁻¹)	0.034±0.009 (15) ^†	0.049±0.009 (9) ^†
k₂ (min⁻¹)	0.091±0.007 (111)	0.128±0.070 (59)
k₃ (min⁻¹)	0.127±0.037 (241)	0.162±0.104 (119)
k₄ (min⁻¹)	0.181±0.082 (94)	0.177±0.062 (52)
DV (mL·mL⁻¹)	0.65±0.13 (6) ^†	0.80±0.07 (2) ^†
DV (Logan) (mL·mL⁻¹)	0.64±0.12 (1) ^†	0.79±0.07 (1) ^†

Tariquidar was administered i.v. at a dose of 2 mg/kg over 30 min at 3 h 20 min before start of the second PET scan.

^†

A statistically significant difference was observed between scan 1 and 2 (Wilcoxon test for paired samples, p<0.05).

Outcome parameters are given as mean±SD averaged over the 5 study subjects. The value in parentheses represents the precision of parameter estimates (expressed as their coefficient of variation in percent), averaged over the 5 study subjects.