Table 2.
Patient Treatment Data from in Italian Opioid Treatment Programs Participating in Project Outcome in 2010. (N = 8,145)
| Variable* | Total Sample |
Buprenorphine (n = 2,257) |
Methadone (n = 5,888) |
p |
|---|---|---|---|---|
| Dose, mean (SD) | — | 8.3 (6.8) | 51.6 (37.9) | — |
| Drug test results | ||||
| Opioid positive 1n (%) | 39,076 (20.7%) | 6,288 (12.6%) | 32,788 (23.7%) | <.001 |
| Cannabis (THC) positive an (%) | 18,950 (21.3%) | 5,444 (19.8%) | 13,506 (22.0%) | <.001 |
| Cocaine positive bn (%) | 19,006 (11.7%) | 4,161 (9.2%) | 14,845 (12.7%) | <.001 |
| Amphetamine positive cn (%) | 345 (0.7%) | 95 (0.6%) | 250 (0.7%) | .061 |
| “Opioid-free days” | ||||
| Total sample (%) | 1,571,044 (78.4%) | 473,734 (87.3%) | 1,097,311 (75.0%) | <.001 |
| Non responders (%) | 25,509 (10.6%) | 3,614 (11.7%) | 21,895 (10.5%) | .000 |
| Partial responders (%) | 104,092 (46.5%) | 17,157 (46.2%) | 86,936 (46.6%) | .169 |
| Responders (%) | 1,441,443 (93.5%) | 452,963 (95.4%) | 988,480 (92.7%) | <.001 |
| Response category | ||||
| Non responderdn (%) | 1,060 (13.0%) | 157 (7.0%) | 903 (15.3%) | <.001 |
| Partial responderen (%) | 952 (11.7%) | 171 (7.6%) | 781 (13.3%) | <.001 |
| Responderfn (%) | 6,133 (75.3%) | 1,929 (85.5%) | 4,204 (71.4%) | <.001 |
| Treatment Adherence g | ||||
| Total, mean (SD) | 74.6 (29.4) | 69.0 (30.6) | 76.6 (28.6) | <.001 |
| Non responder, mean (SD) | 71.8 (29.3) | 63.2 (31.7) | 73.3 (28.6) | <.001 |
| Partial responder, mean (SD) | 72.8 (27.9) | 63.8 (28.6) | 74.8 (27.4) | <.001 |
| Responder, mean (SD) | 75.3(29.7) | 69.9 (31.0) | 77.7 (28.7) | <.001 |
| Number of days in treatment | ||||
| Total sample, mean (SD) | 246.2 (110.1) | 240.5 (111.7) | 248.4 (109.4) | .004 |
| Non responder, mean (SD) | 226.8 (114.8) | 196.0 (121.4) | 232.2 (112.8) | .001 |
| Partial responder, mean (SD) | 234.9 (109.9) | 217.1 (111.2) | 238.9 (109.2) | .019 |
| Responder, mean (SD) | 251.3 (108.8) | 246.2 (109.9) | 253.6 (108.2) | .013 |
Mean (SD) number of opioid urine tests analyzed per patient: 22.2 (18.4); 23.5 (18.3); and, 23.1 (18.4) forbuprenorphine, methadone, and total samples.
No cannabis drug test for: 25.1%; 24.8%; and, 24.9% for buprenorphine, methadone, and total samples.
No cocaine drug test for: 1.5%; 0.8%; and, 1.0% for buprenorphine, methadone, and total samples.
No amphetamine drug test for: 52.5%; 48.0%; and, 49.3% for buprenorphine, methadone, and total samples
Non responder: < 30% “drug-free days” (i.e., total number of days between two negative urine drug tests plus half the number of days between one positive and one negative drug test.
Partial responder: 30% - 60% of “drug-free days.”
Responder: > 60% “drug-free days.”
Treatment adherence is calculated as the percentage of methadone or buprenorphine doses administered ordispensed divided by the doses prescribed.