| CRFR1 |
CRF, Urocortin1 |
3EHS, 3EHU11, 2L2713, |
Stress related pathway |
Depression/Anxiety |
Corticorelin/ Acthrel (approved) |
| CRFR2α |
CRF, Urocortin1, Urocortin2, Urocortin3 |
1U345, 2JND6, 3N96, 3N95, 3N9314
|
Stress related pathway, Cardiac contractility, Angiogenesis |
Depression/Anxiety, Heart failure, Cancer |
|
| PTH1R |
PTH, PTHrP |
3L2J 39, 3C4M10, 3H3G12
|
Ca2+ homeostasis Hyperparathyroidism |
Osteoporosis |
Forteo (approved) Preotact (approved in Europe) |
| PTH2R |
PTH, Tip39 |
– |
Hypothalamic secretion, Nociception |
|
|
| GHRH receptor |
GHRH |
– |
Growth hormone secretion |
Dwarfism |
Tesamorelin (approved) |
| Glucagon receptor |
Glucagon |
– |
Glucose homeostasis |
Type 2 diabetes |
|
| GLP1 receptor |
GLP-1, Exendin4 |
3IOL76, 3C599
|
Insulin secretion |
Type 2 diabetes |
Byetta/Exenatide, Liraglutide (both approved) |
| GLP-2 receptor |
GLP-2 |
|
Glucagon secretion, Gut mucosal growth |
Short bowel syndrome |
Teduglutide (Phase III) |
| GIP receptor |
GIP |
2QKH7
|
Insulin secretion
Lipid metabolism |
Type 2 diabetes |
– |
| PAC1R |
PACAP, VIP |
3N9416, 2JOD8
|
Neurotransmitter, Neuromodulator, Neuroprotection |
Schizophrenia, Medulloblastoma |
– |
| VPAC1R |
VIP, PACAP |
– |
Vasodilation, Digestion, Neuroprotection |
Crohn's disease, rheumatoid arthritis |
– |
| VPAC2R |
VIP, PACAP |
2X57 |
Vasodilation, Digestion, Neuroprotection |
Schizophrenia |
– |
| Secretin receptor |
Secretin |
– |
Pancreatic secretin H2O homeostasis |
|
– |
| Calcitonin receptor |
Calcitonin |
- |
Ca2+ homeostasis |
Osteoporosis |
Miacalcin, Cibacalcin (approved) |
| AMY receptor (CTR /RAMP1,2,3) |
Amylin |
|
Glucose homeostasis |
Diabetes |
Pramlintide/Smylin (approved) |
| CGRP receptor (CLR/RAMP1) |
CGRP |
3N7S15
|
Vasodilation |
Migraine |
Telcagepant (Phase III fail) |
| AM1 receptor (CLR/RAMP2) |
Andromedulin |
2XVT (RAMP2) |
Circulatory system, Vasodilation |
Cardiovascular disease |
|
| AM2 receptor (CLR/RAMP3) |
CGRP, Andromedulin |
|
Vasodilation, Cellular tolerance for oxidative stress |
Cardiovascular diseases |
– |
