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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Acta Neuropathol. 2011 Mar 4;122(1):35–48. doi: 10.1007/s00401-011-0814-2

Figure 2. Progressive axonal degeneration in Twitcher axons.

Figure 2

Confocal imaging revealed different stages of axonal degeneration in Twitcher axons. Z-stacking confocal imaging was performed on longitudinal sections of P30 spinal cord. White arrows point to three different stages of axonal degeneration in the Twitcher mouse (a–c). Orthogonal reconstructions show the YZ and XZ axes. White lines point to selected axonal alterations. These pathological profiles were not detected in any wild type tissue analyzed. 1000x.