Figure 1. Somatic mutations in colon cancer.

a, Number of mutations in each of the MSS, MSI and hypermutated subtypes. b, Transitions and transversions at the individual sample level for the three groups in the same order as shown in a. c, Transitions and transversions averaged across each of the three sample groups. d, Circos plot representation of the whole genome of an MSS and an MSI colon tumour. The outer blue band shows copy number as measured using WGS reads. Red dots indicate somatic non-synonymous, splice-site and stop-gained mutations (MSS genome, 17,651 mutations, average of 6.2 mutations per 10⁶ bases, 3,257 mutated genes; MSI genome, 97,968 mutations, average of 34.5 mutations per 10⁶ bases, 9,851 mutated genes). Grey dots indicate all other somatic mutation types. Orange and grey lines show predicted intra- and interchromosomal rearrangements, respectively.