Table 1.
Baseline | K1 (ml·ml−1·min−1) |
k2 (min−1) |
k3 (min−1) |
k4 (min−1) |
DV (ml·ml−1) |
DV
(Logan) (ml·ml−1) |
---|---|---|---|---|---|---|
0.16±0.05 (20) | 0.36±0.07 (43) |
0.11±0.06 (46) |
0.05±0.02 (24) |
1.27±0.15 (5) |
1.20±0.14 (4) | |
| ||||||
Tariquidar |
K1 (ml·ml−1·min−1) |
k2 (min−1) |
k3 (min−1) |
k4 (min−1) |
DV (ml·ml−1) |
DV (Logan) (ml·ml−1) |
| ||||||
1.5 mg/kg | 0.38±0.17 (11.4) | 0.26±0.07 (29.2) |
0.09±0.03 (61.2) |
0.11±0.08 (20.6) |
2.80±1.05 (6.3) |
2.70±0.91 (1.7) |
2.6 mg/kg | 0.78±0.01 (15.6) | 0.36±0.09 (34.5) |
0.16±0.04 (40.6) |
0.10±0.01 (15.9) |
6.03±1.07 (2.7) |
5.90±1.05 (1.7) |
3.75 mg/kg | 0.81±0.16 (13.9) | 0.18±0.05 (50.3) |
0.20±0.02 (101.3) |
0.22±0.07 (51.4) |
8.92±1.11 (2.3) |
8.80±1.06 (0.9) |
7.5 mg/kg | 1.27±0.24 (17.4) | 0.31±0.12 (82.5) |
0.37±0.10 (97.3) |
0.18±0.01 (23.9) |
12.93±0.79 (1.7) |
12.66±0.77 (0.9) |
15 mg/kg | 1.02±0.02 (15.0) | 0.43±0.16 (50.3) |
0.48±0.04 (39.2) |
0.12±0.02 (20.4) |
12.72±1.83 (1.8) |
12.35±1.79 (1.4) |
30 mg/kg | 1.22±0.23 (11.2) | 0.30±0.04 (54.6) |
0.38±0.18 (59.4) |
0.17±0.09 (19.8) |
13.11±0.22 (2.1) |
12.76±0.04 (0.7) |
| ||||||
Elacridar |
K1 (ml·ml−1·min−1) |
k2 (min−1) |
k3 (min−1) |
k4 (min−1) |
DV (ml·ml−1) |
DV (Logan) (ml·ml−1) |
| ||||||
0.3 mg/kg | 0.13±0.10 (16.5) | 0.29±0.06 (36.5) |
0.14±0.02 (41.4) |
0.07±0.01 (16.7) |
1.28±0.54 (3.1) |
1.22±0.51 (2.9) |
1 mg/kg | 0.57±0.19 (18.1) | 0.33±0.10 (78.9) |
0.29±0.11 (93.2) |
0.19±0.06 (33.3) |
4.49±1.51 (2.9) |
4.47±1.51 (0.9) |
2 mg/kg | 0.92±0.16 (7.2) | 0.18±0.06 (42.2) |
0.29±0.09 (68.5) |
0.22±0.03 (21.1) |
12.00±1.49 (2.4) |
11.72±1.47 (0.6) |
5 mg/kg | 0.93±0.26 (17.0) | 0.22±0.06 (58.8) |
0.28±0.05 (79.7) |
0.16±0.01 (35.4) |
11.40±1.45 (3.8) |
11.16±1.44 (1.1) |
7.5 mg/kg | 0.98±0.08 (6.4) | 0.15±0.02 (43.5) |
0.25±0.07 (55.4) |
0.22±0.04 (30.3) |
14.55±0.06 (2.6) |
14.20±0.13 (0.4) |
Outcome parameters are given as mean±SD averaged over all animals per dose group. The value in parentheses represents the precision of parameter estimates (expressed as their coefficient of variation in percent), averaged over all animals per dose group.