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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Eur J Nucl Med Mol Imaging. 2009 Dec 17;37(5):942–953. doi: 10.1007/s00259-009-1332-5

Table 1.

Outcome parameters (whole brain) of 2T4K model for baseline scans and scans after administration of different tariquidar or elacridar doses

Baseline K1
(ml·ml−1·min−1) 		k2
(min−1) 		k3
(min−1) 		k4
(min−1) 		DV
(ml·ml−1) 		DV (Logan)
(ml·ml−1)
0.16±0.05 (20) 0.36±0.07
(43)		 0.11±0.06
(46)		 0.05±0.02
(24)		 1.27±0.15
(5)		 1.20±0.14 (4)
Tariquidar K1
(ml·ml−1·min−1)		 k2
(min−1)		 k3
(min−1)		 k4
(min−1)		 DV
(ml·ml−1)		 DV (Logan)
(ml·ml−1)
1.5 mg/kg 0.38±0.17 (11.4) 0.26±0.07
(29.2)		 0.09±0.03
(61.2)		 0.11±0.08
(20.6)		 2.80±1.05
(6.3)		 2.70±0.91
(1.7)
2.6 mg/kg 0.78±0.01 (15.6) 0.36±0.09
(34.5)		 0.16±0.04
(40.6)		 0.10±0.01
(15.9)		 6.03±1.07
(2.7)		 5.90±1.05
(1.7)
3.75 mg/kg 0.81±0.16 (13.9) 0.18±0.05
(50.3)		 0.20±0.02
(101.3)		 0.22±0.07
(51.4)		 8.92±1.11
(2.3)		 8.80±1.06
(0.9)
7.5 mg/kg 1.27±0.24 (17.4) 0.31±0.12
(82.5)		 0.37±0.10
(97.3)		 0.18±0.01
(23.9)		 12.93±0.79
(1.7)		 12.66±0.77
(0.9)
15 mg/kg 1.02±0.02 (15.0) 0.43±0.16
(50.3)		 0.48±0.04
(39.2)		 0.12±0.02
(20.4)		 12.72±1.83
(1.8)		 12.35±1.79
(1.4)
30 mg/kg 1.22±0.23 (11.2) 0.30±0.04
(54.6)		 0.38±0.18
(59.4)		 0.17±0.09
(19.8)		 13.11±0.22
(2.1)		 12.76±0.04
(0.7)
Elacridar K1
(ml·ml−1·min−1)		 k2
(min−1)		 k3
(min−1)		 k4
(min−1)		 DV
(ml·ml−1)		 DV (Logan)
(ml·ml−1)
0.3 mg/kg 0.13±0.10 (16.5) 0.29±0.06
(36.5)		 0.14±0.02
(41.4)		 0.07±0.01
(16.7)		 1.28±0.54
(3.1)		 1.22±0.51
(2.9)
1 mg/kg 0.57±0.19 (18.1) 0.33±0.10
(78.9)		 0.29±0.11
(93.2)		 0.19±0.06
(33.3)		 4.49±1.51
(2.9)		 4.47±1.51
(0.9)
2 mg/kg 0.92±0.16 (7.2) 0.18±0.06
(42.2)		 0.29±0.09
(68.5)		 0.22±0.03
(21.1)		 12.00±1.49
(2.4)		 11.72±1.47
(0.6)
5 mg/kg 0.93±0.26 (17.0) 0.22±0.06
(58.8)		 0.28±0.05
(79.7)		 0.16±0.01
(35.4)		 11.40±1.45
(3.8)		 11.16±1.44
(1.1)
7.5 mg/kg 0.98±0.08 (6.4) 0.15±0.02
(43.5)		 0.25±0.07
(55.4)		 0.22±0.04
(30.3)		 14.55±0.06
(2.6)		 14.20±0.13
(0.4)

Outcome parameters are given as mean±SD averaged over all animals per dose group. The value in parentheses represents the precision of parameter estimates (expressed as their coefficient of variation in percent), averaged over all animals per dose group.