Table 2.
Outcome parameters of 2T4K model for paired VPM PET scans before and after 3 mg/kg tariquidar in different brain regions
|
Brain region
Before inhibition |
K1 (ml·ml−1·min−1) |
k2 (min−1) |
k3 (min−1) |
k4 (min−1) |
DV (ml·ml−1) |
DV (Logan) (ml·ml−1) |
|
| ||||||
| Cerebellum | 0.19±0.04 (12.8) |
0.28±0.06 (30.1) |
0.11±0.05 (35.9) |
0.05±0.02 (19.3) |
2.23±0.40 (5.2) |
1.99±0.37 (3.7) |
| Frontal motor cortex |
0.17±0.07 (12.3) |
0.22±0.09 (33.1) |
0.12±0.07 (41.1) |
0.05±0.02 (24.3 |
2.38±0.67 (6.0) |
2.12±0.69 (3.0) |
| Corpus striatum | 0.11±0.03 (15.5) |
0.26±0.07 (39.5) |
0.11±0.05 (45.2) |
0.04±0.02 (25.0) |
1.50±0.31 (7.8) |
1.31±0.29 (4.4) |
| Entorhinal cortex | 0.20±0.04 (18.5) |
0.32±0.10 (38.2) |
0.11±0.04 (46.1) |
0.05±0.02 (26.3) |
2.08±0.20 (6.4) |
1.88±0.19 (3.5) |
| Hippocampus | 0.11±0.03 (17.7) |
0.30±0.07 (44.0) |
0.12±0.04 (49.6) |
0.05±0.01 (26.3) |
1.28±0.15 (6.8) |
1.17±0.19 (4.2) |
| Thalamus | 0.11±0.01 (18.7) |
0.26±0.08 (36.8) |
0.10±0.04 (55.2) |
0.05±0.01 (35.2) |
1.35±0.25 (7.9) |
1.21±0.19 (4.5) |
|
| ||||||
|
| ||||||
|
Brain region
After inhibition |
K1 (ml·ml−1·min−1) |
k2 (min−1) |
k3 (min−1) |
k4 (min−1) |
DV (ml·ml−1) |
DV
(Logan) (ml·ml−1) |
|
| ||||||
| Cerebellum | 0.73±0.14 (11.7) |
0.32±0.13 (46.6) |
0.30±0.08 (75.2) |
0.20±0.05 (26.4) |
6.14±0.54 (2.9) |
6.07±0.52 (0.9) |
| Frontal motor cortex |
0.63±0.08 (9.5) |
0.24±0.05 (49.6) |
0.32±0.09 (68.7) |
0.19±0.06 (23.8) |
7.33±0.82 (1.7) |
7.14±0.80 (0.9) |
| Corpus striatum | 0.79±0.13 (10.5) |
0.28±0.08 (46.6) |
0.47±0.22 (53.4) |
0.22±0.06 (23.1) |
8.89±1.08 (2.7) |
8.70±1.05 (0.6) |
| Entorhinal cortex | 0.64±0.17 (12.9) |
0.37±0.14 (57.5) |
0.34±0.10 (68.9) |
0.15±0.05 (22.5) |
6.20±1.40 (3.4) |
6.09±1.37 (1.1) |
| Hippocampus | 0.75±0.11 (11.1) |
0.32±0.08 (57.9) |
0.43±0.09 (69.4) |
0.18±0.05 (23.8) |
8.17±0.91 (2.2) |
8.01±0.88 (0.9) |
| Thalamus | 0.93±0.12 (9.0) |
0.33±0.18 (48.8) |
0.47±0.11 (64.4) |
0.23±0.06 (23.6) |
9.64±1.06 (2.0) |
9.45±1.03 (0.6) |
Outcome parameters are given as mean±SD averaged over the 6 studied animals. The value in parentheses represents the precision of parameter estimates (expressed as their coefficient of variation in percent), averaged over the 6 studied animals.