Figure 5. Summary data showing that in rats with ‘patent femoral arteries’ that neither retrograde nor anterograde injection of the EP4 antagonist (1 μg) attenuated the exercise pressor reflex.

Number signs (#) represent significant differences (P < 0.05) in TTIs between retrograde and anterograde conditions both before and after injection of L161982, EP4 antagonist. For purposes of comparison, the data shown in Fig. 3 A–C (i.e. retrograde injection) have been repeated in this figure. Cross (†) represents a significant difference (P < 0.05) between the freely perfused baseline value before and after the antagonist. EP, endoperoxide; HR, heart rate; MAP, mean arterial pressure; TTI, tension-time index.