Figure 3.

Loop 7 morphology in yeast ENTH2 WT and ENTH2^DEQ and human ENTH1. A: Loop 7 of yeast ENTH2 WT and ENTH2^DEQ are shown in green and cyan, respectively. Residues 112 and 118 in both structures form a hydrogen bond. B: Loop 7 of yeast ENTH2 WT and ENTH2^DEQ and the first reported solution structure from the family of PDB's corresponding to human ENTH1 are shown in green, cyan, and magenta, respectively. Structures are superimposed using residues 110–120. Loop 7 of human ENTH1 is also shown as a surface representation, depicting an open pocket flanked by charged residues.