Table 3.

Odds ratios for associations with diagnosis of Major Depression from the univariate and final multivariable model

Variables	Unadjusted Odds Ratio	Adjusted Odds Ratio	95% Confidence Limits	P value
Natural Log of Mean DHEA-S level	0.99	0.95	0.72, 1.26	0.72
Menopausal Status	Unadjusted p****≤0.0001			Adjusted p =0.0002***
Premenopause	Reference	Reference	Reference
Late Premenopause	1.23	1.20	0.84, 1.70	0.32
Early Transition Perimenopause	0.63**	0.70	0.47, 1.04	0.07
Late Transition Perimenopause	0.28***	0.27	0.15, 0.64	0.006**
Postmenopause	0.35**	0.39	0.15, 1.01	0.053
Age >41	0.52****	0.67	0.47, 0.96	0.029*
Race group African American	2.50****	2.14	1.37, 3.36	0.0009***
Smoker	1.98***	1.78	1.23, 2.61	0.002**
Body Mass Index	1.02*	1.03	1.01, 1.05	0.01**
Natural Log of Mean Testosterone Levels1	1.01	1.05	0.88, 1.24	0.61
Natural Log of Mean Estradiol Levels1	1.05	1.06	0.85, 1.32	0.60

P values for analyses

^*≤0.05

^**≤0.01

^***≤0.001

^****≤0.0001

¹Not included in baseline multivariable model, only included to measure metabolite effect