Table IV.
Uterine histology of Tsc1-deleted mice.
| Age (days) | Genotype | No. of mice examined | Uterine histology | Mice with indicated histology (%) |
|---|---|---|---|---|
| 30 | Tsc1PR(f/f) | 8 | Normal | 8 (100%) |
| Tsc1PR(d/d) | 8 | Simple hyperplasiaa | 5 (62.5%) | |
| Complex hyperplasia with luminal hyperplasia | 2 (25%) | |||
| Complex hyperplasia | 1 (12.5%) | |||
| 60 | Tsc1PR(f/f) | 7 | Normal | 7 (100%) |
| Tsc1PR(d/d) | 9 | Moderate to marked simple hyperplasia | 9 (100%) | |
| 90 | Tsc1PR(f/f) | 7 | Normal | 6 (85.8%) |
| Mild simple hyperplasia | 1 (14.2%) | |||
| Tsc1PR(d/d) | 8 | Simple hyperplasia | 8 (100%) | |
| Survivalb | Tsc1PR(f/f) | 8 | Normal | 6 (75%) |
| Simple hyperplasia | 2 (25%) | |||
| Tsc1PR(d/d) | 6 | Simple hyperplasia, stromal polyp with stromal overgrowth | 4 (66.6%) | |
| Simple hyperplasia with focal atypia, stromal polyp with stromal overgrowth | 1 (16.7%) | |||
| Marked simple hyperplasia Leiomyosarcoma | 1 (16.7%)c |
aRelative to normal epithelium.
bTsc1PR(f/f), 323–383 days old; Tsc1PR(d/d), 271–308 days old.
cThis uterus possibly has a malignant spindle cell tumor.