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. Author manuscript; available in PMC: 2013 Jun 24.
Published in final edited form as: Mol Cancer Res. 2012 Feb 21;10(4):523–534. doi: 10.1158/1541-7786.MCR-11-0530

Figure 7.

Figure 7

Hsf4 deficiency mediates senescence in normal and tumor tissue in vivo. A, representative normal tissue sections stained for SA-β-gal activity (blue staining). Bar = 10 μm. B, representative tumor tissue sections stained for SA-β-gal activity (blue staining). Bar = 10 μm. C, immunofluorescence staining of p27 and p21 in representative histologic sections of thymomas (n = 4–6) and sarcomas (n = 5–7) that developed in p53 and hsf4p53-deficient mice. Arrows show representative cells with nuclear staining for p27 or p21. Bar = 5 μm.