Fig. 5.

Comparison between LcαE7-diethylphosphate (magenta) and AChE-methylphosphate (green) after aging of AChE-dimethylphosphate (3GEL; T. californica). Right is rotated 90° from Left. The active sites and substrate binding sites are generally highly conserved. The key differences between the structures include the closer distance (2.7 vs. 3.2 Å) between H440 and the side chain oxygen of the adduct in AChE, the absence of a residue at an analogous position to AChE F331 in LcαE7, and the replacement of W84 in AChE by Y457 in LcαE7.