Table 1.
Antibacterial activity of small molecule inhibitors
| Inhibitor | S. flexneri | B. anthracis | M. smegmatis | E. coli ∆tolC | E. coli ∆tolC ∆ssrA | |||||
| MIC* | MBC† | MIC | MBC | MIC | MBC | MIC | MBC | MIC | MBC | |
| KKL-35 | 6.0 (0) | S‡ | 3.0 (2.6) | S | 1.3 (0.4) | 1.3 (0.4) | 0.3 (0.1) | ND | 0.3 (0.1) | ND |
| KKL-52 | 50 (0) | S | 1.5 (0) | 6.0 (0) | 100 (0) | 100 (0) | 4.0 (0) | ND | 4.0 (0) | ND |
| KKL-10 | 7.8 (5.5) | S | 2.3 (0.3) | 7.5 (6.4) | 1.5 (0) | 1.5 (0) | 0.4 (0) | ND | 0.4 (0) | ND |
| KKL-22 | 19 (11) | S | 10 (3.5) | 25 (0) | 5.0 (1.7) | 5.0 (1.7) | 1.5 (0) | ND | 1.5 (0) | ND |
| KKL-55 | 13 (9.0) | S | 25 (0) | 50 (0) | 25 (0) | 25 (0) | 16 (7.5) | ND | 16 (7.5) | ND |
ND, not determined.
*
Mean (SD) values from at least three broth microdilution assays (μM).
†
Mean (SD) values from at least three plating assays (μM).
‡
Bacteriostatic at all tested concentrations.