Table 4.
PK of temsirolimus and sirolimus after a 10 mg dose of temsirolimus
| Without sorafenib (n = 6) |
With sorafenib at steady state (n = 4 or 5) |
|||
|---|---|---|---|---|
| TEM | SIR | TEM | SIR | |
| Cmax (µg/l) | 257 ± 54.2 | 22.0 ± 5.32 | 257 ± 29.2 | 33.1 ± 15.8 |
| Tmax (h) | 1 | 17.8 ± 17.8 | 1 | 8 ± 9 |
| T1/2 (h) | 22. ± 4.42 | 73.4 ± 17.5 | 18.3 ± 5.16 | 133 ± 115 |
| AUC0-168 h (h·µg/l) | 2220 ± 415 | 2062 ± 582 | 1664 ± 435 | 2495 ± 1329 |
| AUCinf (h·µg/l) | 2356 ± 435 | 2635 ± 908 | 1761 ± 390a | 3707 ± 2198 |
| AUCsum (h·µg/l) | – | 4991 ± 861 | 5521 ± 2257 | |
| CL (l/h) | 4.37 ± 0.808 | 4.21 ± 1.54 | 5.86 ± 1.01a | 4.93 ± 5.41 |
| Vdss (l) | 86.6 ± 23.0 | 454.3 ± 183 | 61.3 ± 32.5 | 335 ± 192 |
aStatistical t-test, P < 0.05. TEM = temsirolimus; SIR = sirolimus.