Table 1.

Summary of genome-wide integrative analysis of endoxifen sensitivity in 60 CEU LCLs

SNP information		SNP–phenotype association (P-value)				SNP–target gene association (P-value)	Target gene–phenotype association (P-value)
SNP ID	Chromosome (position)	3 μM	5 μM	7 μM	10 μM		3 μM	5 μM	7 μM	10 μM
rs17394957	Chr. 1 (159 580 061)	0.003	4 × 10−5	0.002	0.024	GLTSCR2 (3 × 10−6)	0.386	0.014	0.171	0.048
rs13064915	Chr. 3 (138 603 933)	0.010	0.003	5 × 10−5	0.013	ILVBL (1 × 10−6)	0.055	0.003	0.004	0.007
						SNRPB (3 × 10−6)	0.098	0.025	0.096	0.168
rs478437	Chr. 7 (144 424 767)	0.016	0.007	0.040	6 × 10−5	USP7 (9 × 10−7)	0.014	0.013	0.027	0.007
rs8068198	Chr. 17 (68 597 219)	0.007	1 × 10−5	0.001	0.0045	SYT17 (3 × 10−6)	0.226	0.026	0.104	0.048
rs310786	Chr. 12 (75 960 279)	0.445	0.069	0.012	5 × 10−5	TMPRSS3 (1 × 10−6)	0.243	0.045	0.009	0.006
rs1534882	Chr. 22 (35 659 491)	0.093	0.003	1 × 10−5	5 × 10−5	KLF7 (3 × 10−6)	0.654	0.001	0.002	0.001
						TES (1 × 10−6)	0.717	0.294	0.085	0.328
						GPR55 (2 × 10−6)	0.896	0.253	0.066	0.123
rs738149	Chr. 22 (35 660 195)	0.096	0.002	7 × 10−6	3 × 10−5	SMARCA2 (2 × 10−6)	0.683	0.078	0.023	0.021
						GPR55 (3 × 10−6)	0.896	0.253	0.066	0.123