Table 2.

Risk of colorectal polyps associated with CRP genotypes¹

	Controls (N=562)	Adenomas (N=477)		Concurrent adenomas and hyperplastic polyps (N=112)
	N	N	OR (95% CI)	N	OR (95% CI)
CRPGenotype
−821A>G rs2794521
AA	294	245	1.0 (ref.)	61	1.0 (ref.)
AG	217	180	1.0 (0.7-1.3)	41	0.8 (0.5-1.3)
GG	51	53	1.4 (0.9-2.1)	11	1.2 (0.5-2.5)
−390C>T/A rs3091244 (all genotypes)
CC	221	196	1.0 (ref.)	43	1.0 (ref.)
CT	215	181	1.0 (0.7-1.3)	43	1.1 (0.6-1.8)
CA	56	37	0.9 (0.6-1.5)	12	1.5 (0.7-3.2)
TT	42	42	1.1 (0.7-1.8)	10	1.1 (0.5-2.4)
AA	4	1	0.2 (0.1-1.4)	0	0 (--)
TA	25	20	0.9 (0.4-1.6)	4	0.8 (0.3-2.7)
−390C>T/A rs3091244 (grouped by putative phenotype as in [15])
CC	221	196	1.0 (ref.)	43	1.0 (ref.)
CT or CA	271	218	1.0 (0.7-1.3)	55	1.2 (0.7-1.7)
TT, AA, or TA	71	63	1.0 (0.6-1.4)	14	0.9 (0.4-1.8)
90A>T rs1417938
AA	281	236	1.0 (ref.)	57	1.0 (ref.)
AT	239	200	1.0 (0.8-1.3)	46	1.0 (0.6-1.5)
TT	43	42	1.1 (0.6-1.8)	10	1.0 (0.4-2.1)
838G>C rs1800947 (L184L)
GG	504	414	1.00(ref.)	94	1.0 (ref.)
GC or CC	59	64	1.4 (0.9-2.1)	19	2.0 (1.1-3.6)
2043G>A rs1205
GG	241	218	1.0 (ref.)	50	1.0 (ref.)
GA	262	210	0.9 (0.7-1.2)	51	1.0 (0.6-1.7)
AA	60	50	0.9 (0.6-1.4)	12	1.1 (0.5-2.2)
4363C>A rs3093075
CC	477	419	1.0 (ref.)	96	1.0 (ref.)
CA or AA	86	57	0.9 (0.6-1.3)	16	1.1 (0.6-2.0)
CRPhaplotype2(−821A>G; −390C>T/A; 90A>T; 838G>C; 2043G>A; 4363C>A)
GCAGGC	28.6	29.3	1.0 (ref.)	26.9	1.0 (ref.)
ATTGGC	28.4	29.7	1.0 (0.9-1.2)	30.0	1.1 (0.8-1.4)
ACAGGC	1.3	1.9	1.2 (0.8-1. 8)	2.6	1.5 (0.8-2.8)
ACAGAC	28.1	25.1	0.9 (0.8-1.1)	24.3	1.0 (0.7-1.3)
ACACAC	5.2	7.1	1.2 (0.9-1.6)	7.8	1.6 (1.0-2.5)
AAAGGA	8.1	6.3	0.9 (0.7-1.2)	7.0	1.1 (0.7-1.78)
all rare haplotypes	0.4	0.8	1.5 (0.7-3.1)	1.3	2.0 (1.0-3.8)
			global p=0.63		global p=0.49

¹Age and sex adjusted.

²Percents rather than total N are reported for haplotypes since they are inferred rather than determined.