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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Apr 30;23(12):3481–3486. doi: 10.1016/j.bmcl.2013.04.055

Table 2.

Bacillus anthracis and Staphyloccocus aureus helicase inhibition by benzobisthiazole compounds 34–45.

graphic file with name nihms474614u2.jpg
Compd. R1 IC50 Ba Helicase (μM)
34 cyclopropyl >100
35 CH2Ph 47
36 CH2CH2Ph >100
37 graphic file with name nihms474614t1.jpg >100
38 graphic file with name nihms474614t2.jpg >100
39 graphic file with name nihms474614t3.jpg >50
40 graphic file with name nihms474614t4.jpg >100
41 2-furan 102
42 2-thiophene 90
43 graphic file with name nihms474614t5.jpg >50
44 graphic file with name nihms474614t6.jpg >50
45 2-pyrazine 28