TABLE 1.
Imaging findings at baseline
| No. | First diagnosis (F) / recurrent disease (R) | # of CNS lesions on MRI | Location and size of lesions on MRI | MRI pre/post biopsy | Extent of biopsy | Steroid treatment | Interval between MRI and PET (days) | # of CNS lesions on PET | Location of pathologically increased focal FDG uptake according to visual analysis | SUVmax | Uptake ratio | Whole-body PET |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 1 | left thalamus | post | Stereotactic | yes | 14 | 0 | normal | |||
| 2 | F | 3 | left temporal (2.2×1.25cm) | pre | Stereotactic (left temporal lesion) | yes | 14 | 2 | left temporal | 4.1 | 1.7 | normal |
| right frontal | right frontal | 4.2 | 1.2 | |||||||||
| left cerebellum | ||||||||||||
| 3 | R | 1 | right parieto-occipital (4×2cm) | NA | No biopsy | no | 7 | 1 | right parieto-occipital | 9.7 | 3.3 | Pathologically increased FDG-uptake in lung, thoracic wall and mediastinal lymph nodes (n=11) |
| 4 | F | 1 | left parieto-temporo-occipital (3×3cm) | pre | Stereotactic | yes | 14 | 1 | left parieto-temporo-occipital | 4.2 | 1.4 | Pathologically increased FDG-uptake in left kidney/adrenal gland (stable in follow-up PET) |
| 5 | F | 3 | right frontal (3×1.8cm) | pre | Open resection of right frontal lesion | yes | 7 | 2 | low FDG-Uptake after open resection right frontal | normal | ||
| left parietal (2×1.4cm) | left parietal | 10.7 | 1.5 | |||||||||
| right parietal (2cm×1.5) | right parietal | 12.5 | 1.5 | |||||||||
| 6 | F | 1 | residual contrast enhancement in right cerebellum (postoperative) | post | Open resection of right cerebellar lesion | yes | 28 | 3 | right cerebellum | 4.3 | 1.2 | normal |
| right striatum | 6.0 | 1.2 | ||||||||||
| midbrain | 4.6 | 1.2 | ||||||||||
| 7 | F | 1 | right fronto-parietal (4.5×2.5cm) | post | Open resection | yes | 21 | 1 | right fronto-parietal | 3.6 | 3.5 | normal |
| 8 | F | 1 | pituitary gland (1×1cm) | post | Open biopsy | no | 10 | 1 | pituitary gland | 8.7 | 1.2 | normal |
| 9 | R | 1 | right cerebellum (3×2cm) | NA | No biopsy | no | 7 | 1 | right cerebellum | 10.0 | 1.8 | normal |
| 10 | R | mult | left cerebellum (3.75×2cm) | NA | No biopsy | yes | 23 | 0 | normal |
CNS = central nervous system; MRI = magnetic resonance imaging; SUVmax = maximal standard uptake value; TU = tumour; PET = positron emission tomography; NA = not applicable; FDG = F-18-fluorodeoxyglucose; mult = multiple