TABLE 3.

Oral antibiotics in the treatment of skin rash

Reference	Patients (n)	Patient characteristics	Antibiotic	Duration of skin treatment	Endpoint	Assessment tools	Skin toxicity Results Placebo vs intervention	Skin-related quality of life
NCCTG N03CB-Jatoi et al., 200839	61	Lung/gastrointestinal/other patients treated with gefitinib, cetuximab, erlotinib/other investigational agent	Tetracycline	500mg bid 4 weeks	Incidence of Grade >2 skin rash, QoL	NCI-CTCAE version 3.0, Skindex 16	76% vs 70% developed a rash. Grade 2 55% vs 17% at week 4	Less skin irritation, burning or stinging (Skindex-16) in tetracycline arm
Supplementary NCCTG N03CB-Jatoi et al., 201140	65	As above	Tetracycline	500mg bid 4 weeks	Incidence of Grade >2 skin rash, QoL	NCI-CTCAE version 3.0, Skindex 16 and LASA.	Grade 2 identical	Identical (Skindex-16)
Scope et al., 200741	48	mCRC patients treated with cetuximab	Minocycline	100mg/d 8 weeks	Total facial lesion counts;	Photography and patient-assessed rash severity and other cutaneous changes	Lower facial lesion count during weeks 1–4 in minocyline arm (p=0.005), Less severe facial rash (42% vs 20%	Less severe itching in minocycline arm, 50% vs 20% (p=0.05)
Lacouture et al., 201015	95	Previously treated mCRC patients treated with panitumumab-containing therapy;	Doxycycline	100mg bid 6 weeks + skin moisturizer and sunscreen	Prophylactic vs reactive. incidence of protocol specified Grade >2 skin rash, QoL	NCI-CTCAE version 3.0, DLQI	Grade 2 reduced from 62% in the reactive group to 29% in the prophylactic group	Better (DLQI) in prophylactic group; change from baseline score less for prophylactic than reactive group
Deplanque et al., 201042	147	Non-small cell lung cancer patients treated with erlotinib; all	Doxycycline	100 mg/d 4 months	Incidence of erlotinib folliculitis	NCI-CTCAE version 3.0	Incidence 82% vs 68%, Grade ≥2 reduced from 82% to 39%, also significant decrease in other cutaneous AEs.	na

AEs = adverse events; DLQI = Dermatological Life Quality Index; na = not available; NCI-CTCAE = National Cancer Institute Common Terminology Criteria for Adverse Events; mCRC = metastatic colorectal cancer