Figure 3. Application of the Neurologic Signature to Physical and Social Pain Stimuli in Study 3.

Panel A shows the signature response in each condition. The dashed horizontal line shows the threshold derived from the classification of pain versus warmth in study 1. I bars indicate standard errors. Panel B shows the receiver-operating-characteristic plots for the forced-choice test, assessed only from the pattern within a single region of interest. A physical-pain signature would ideally show high sensitivity and specificity for pain versus warmth (orange line) and pain versus rejecter (dark blue line) but chance performance for rejecter versus friend (light blue line). The brain images (insets) show the positive (yellow) and negative (blue) signature weights in each region of interest, with the magnitude of the weights represented by the intensity of the color.