. Author manuscript; available in PMC: 2014 Apr 1.

Published in final edited form as: Trends Pharmacol Sci. 2013 Feb 27;34(4):215–225. doi: 10.1016/j.tips.2013.01.008

Table 1.

Residue preference for BACE1 substrates

Position	Amino acid residues preference
P4′	Asp > Glu > Trp > Tyr > Phe^a
P3′	Leu > Trp > Val > Ile > Thr > Asp > Glu
P2′	Val > Ile > Ala > Glu > Leu
P1′	Met > Glu > Gln > Ala > Asp
P1	Leu > Phe > Met > Tyr > Thr
P2	Asp > Asn > Met > Phe > Tyr > Leu > Glu > Ser > Ala > Gln > Lys
P3	Ile > Val > Leu > Glu > His
P4	Glu > Gln > Asp > Met > Asn
P5	Asp > Phe > Tyr > Glu > Trp > Thr > Pro > Ser
P6	Phe > Trp > Asp > Ile > Leu
P7	Ile > Asp > Trp > Tyr > Phe > Glu
P8	Arg > Tyr > Phe > Gln > Glu

The residues found in native APP (labeled in blue) or Swedish mutant APP (labeled in red).