Table 2.
BACE1 substrates
| Name | Cleavage sites | Related phenomenon | |
|---|---|---|---|
| P1 | P1′ | ||
| APP | M | D | Aβ generation |
| APLP1 | Ma | Na | AICD generation |
| APLP2 | L | D | AICD generation |
| NRG1 | F | M | Axonal myelination |
| Voltage-gated sodium channels | L/F | E/Q | Reduced neuron cells excitability |
| PSGL-1 | L | S | Reduced leukocyte adhesion |
| ST6Gal1 | L | Q | Acute-phase hepatic reactions |
| LRP | Unknown | Unknown | LRP ectodomain releasing |
| mPGES-2 | La | Sa | Increased PGE-2 levels |
| IL-1R2 | Fa | Qa | Block NF-κB signal |
| Enterokinase | GYEb | Unknown | |
a
To be the possible cleavage site by analysis: relative kcat/Km [108].
b
Potential BACE1 cleavage site.