Table 3.
BACE1-binding partners
| Name | Function | Binding domain | |
|---|---|---|---|
| BACE1 | Partner | ||
| GGA | BACE1 trafficking | ACDL | VHS |
| PLSCR1 | BACE1 distribution | Dileucine motif | Cytoplasmic domain |
| RTN3/4 | Inhibit BACE1 cleavage | Cytoplasmic domain | Cytoplasmic domain |
| LR-II (sorLA) | Switch BACE1 to α/β cleavage | Cytoplasmic domain | Cytoplasmic domain |
| PAR-4 | BACE1 activity positive effector | Cytoplasmic domain | Cytoplasmic domain |
| PS1 | BACE1 maturation | Unknown | Unknown |
| CCS | Reduce SOD1 activation | Cytoplasmic domain | N-terminal domain |
| BRI3 | Unknown | Cytoplasmic domain | Cytoplasmic domain |
| APP | BACE1 endocytosis | Ectodomain | Ectodomain |
| Nicastrin (in vitro) | BACE1 activation | Unknown | Unknown |
| Sortlin | BACE1 retrograde trafficking | Ectodomain | Unknown |
| PrPc | APP processing of BACE1 | Ectodomain | Unknown |