. Author manuscript; available in PMC: 2013 Jun 24.

Published in final edited form as: Osteoporos Int. 2010 Dec 9;22(4):1079–1090. doi: 10.1007/s00198-010-1296-0

Table 4.

Single Nucleotide Polymorphisms and Genes Associated with vertebral Cross-Sectional Area Among Older Men.

				Discovery Sample		Validation Sample		Pooled Sample
				Adjustment 1		Adjustment 1		Adjustment 1		Adjustment 2
Gene	SNP	Alleles	Frequency	β	p-value	β	p-value	β	p-value	β	p-value	r²
CYP11B1	rs6410	G-->A	0.46	−0.4771	0.0036^R	−0.2755	0.0311 ^R	−0.3686	0.00025 ^R	−0.2896	0.0018 ^R	0.0048
DVL2	rs1215	A-->G	0.15	1.1240	0.0059 ^R	1.0219	0.0192 ^R	0.9254	0.0019 ^R	0.1684	0.0279 ^A	0.0020
DLX5	rs6960249	A-->C	0.45	−0.4086	0.0134 ^R	−0.2577	0.0546 ^R	−0.3035	0.0035 ^R	−0.2031	0.0336 ^R	0.0021
WNT4	rs7517829	A-->G	0.42	0.2154	0.0231^A	0.2712	0.0494 ^R	0.3034	0.0051 ^R	0.2741	0.0059 ^R	0.0046
PAX7	rs2236817	C-->A	0.12	0.4623	0.0009 ^A	0.9597	0.0203 ^R	0.2527	0.0040 ^A	0.2196	0.0066 ^A	0.0050

Additive and recessive models were tested for each SNP and the regression parameter and p-value from the most significant genetic model (additive ore recessive) is shown.

: p-value from the additive model;

: p-value from recessive model

^b)

Minor allele frequency in the pooled sample

^b)

Adjustment 1: Age, clinic site, population sub-structure

^c)

Adjustment 2: Age, clinic site, population sub-structure, height, body weight

^d)

Amount of variation explained after adjusting for age, site, population sub-structure, height, body weight