Table 7. Liver and plasma chemistries of ADOX OB mice at 10 days p.t.
| ADOX OB 10 D | ||||||
| Fasted | Refed | |||||
| Phenotype (n) | GFP (4) | Ildr2 (4) | P-value | GFP (4) | Ildr2 (4) | P-value |
| Body weight (g) | 45.1±1.4 | 48.2±0.6 | 0.120 | 46.9±1.1 | 43.7±0.8 | 0.066 |
| Liver weight (g) | 3.4±0.2 | 3.9±0.3 | 0.321 | 4.6±0.3 | 3.4±0.1 | 0.042 |
| Hepatic TG (mg/g Liver) | 49.5±5.7 | 27.1±3.0 | 0.019 | 56.4±4.4 | 32.3±4.0 | 0.007 |
| Hepatic TCH (mg/g Liver) | 7.7±0.6 | 5.6±0.2 | 0.038 | 6.4±0.2 | 5.1±0.29 | 0.015 |
| Hepatic glycogen (mg/g Liver) | 50.4±4.3 | 53.5±3.7 | 0.606 | 62.8±101.6 | 61.3±103.6 | 0.689 |
| Plasma glucose (mg/dL) | 151±10 | 174±24 | 0.420 | 224±29 | 263±20 | 0.349 |
| Plasma insulin (µg/L) | 13.6±4.4 | 24.5±2.5 | 0.168 | 73.9±19.1 | 89.3±4.0 | 0.489 |
| Plasma TG (mg/dL) | 94.3±27.2 | 129.8±43.4 | 0.538 | 137.6±18.3 | 135.4±11.7 | 0.925 |
| Plasma TCH (mg/dL) | 134.0±3.5 | 129.0±3.9 | 0.383 | 143.1±4.8 | 130.9±2.6 | 0.086 |
| Plasma FFA (mEq/L) | 1.66±0.09 | 1.46±0.05 | 0.119 | 2.25±0.29 | 1.76±0.12 | 0.206 |
| Plasma ALT (mU/L) | 115.1±18.4 | 109.7±15.7 | 0.668 | 108.0±5.4 | 100.1±15.3 | 0.386 |
| Plasma AST (mU/L) | 106.1±8.8 | 101.7±13.8 | 0.611 | 102.7±12.7 | 98.7±17.0 | 0.718 |
Mice were chow-fed, 10-week-old B6.V-Lepob/J (OB) males, intravenously injected with ADOX vectors expressing GFP or Ildr2. Measurements were taken at 10 days p.t. (following either a 24-hr fast “Fasted” or following a 24 hr fast and 12 hr refeeding “Refed”). n = number of animals in each study. Data shown are mean ± SEM; P values were calculated by 2-tailed t test. TG, triglycerides; TCH, total cholesterol; FFA, free fatty acids; ALT, alanine aminotransferase; AST, aspartate aminotransferase.