Figure 6. Role of S1P in GSC survival properties.

U–SC (A) and L0627 cells (B) were exposed to 50-200 µM of TMZ alone (♦) or in combination with 4 µM SKI (●). After 48 hours of treatment, cell viability was assessed by the MTT assay. Results are expressed as percentage of cell viability with respect to vehicle-treated cells (♦) or cells treated with SKI alone (●) (100%). Data are the mean ± SD of three independent experiments. * p < 0.05; ** p < 0.01 vs vehicle-treated cells.