Table 1. Frequency of Genotype and Allele Polymorphisms of GAK rs1564282 among PD and Controls in Taiwan, Singapore and China.
PD (%) | Controls (%) | OR (95% CI) | P-value | |
Taiwan | ||||
CC | 381(78.9) | 387(78.2) | 1.00 | |
CT | 97(20.1) | 104(21.0) | 0.95(0.69–1.29) | 0.73 |
TT | 5(1.0) | 4(0.8) | 1.27(0.32–5.35) | 0.74 |
CT+TT | 102(21.1) | 108(21.8) | 0.96(0.71–1.30) | 0.79 |
Common (C) allele | 859(88.9) | 878(88.7) | 1.00 | |
Minor (T) allele | 107(11.1) | 112(11.3) | 0.98(0.74–1.29) | 0.87 |
Singapore | ||||
CC | 306(78.9) | 311(79.9) | 1.00 | |
CT | 77(19.8) | 77(19.8) | 1.02(0.71–1.45) | 0.93 |
TT | 5(1.3) | 1(0.3) | 5.07(0.69–121.3) | 0.12 |
CT+TT | 82(21.1) | 78(20.1) | 1.06(0.75–1.51) | 0.71 |
Common (C) allele | 689(88.8) | 699(89.8) | 1.00 | |
Minor (T) allele | 87(11.2) | 79(10.2) | 1.12(0.81–1.54) | 0.50 |
Merged (Taiwan + Singapore) | ||||
CC | 687(78.9) | 698(78.9) | 1.00 | |
CT | 174(20.0) | 181(20.5) | 0.98(0.77–1.23) | 0.84 |
TT | 10(1.1) | 5(0.6) | 2.03(0.69–6.61) | 0.20 |
CT+TT | 184(21.1) | 186(21.1) | 1.01(0.80–1.27) | 0.99 |
Common (C) allele | 1548(88.9) | 1577(89.2) | 1.00 | |
Minor (T) allele | 194(11.1) | 191(10.8) | 1.035(0.84–1.28) | 0.75 |
China | ||||
CC | 616(75.9) | 616(80.8) | 1.00 | |
CT | 183(22.5) | 142(18.6) | 1.29(1.01–1.65) | 0.04 |
TT | 13(1.6) | 4(0.5) | 3.25(1.10–11.61) | 0.03 |
CT+TT | 196(24.1) | 146(19.2) | 1.3(1.05–1.71) | 0.02 |
Common (C) allele | 1415(87.1) | 1374(90.2) | 1.00 | |
Minor (T) allele | 209(12.9) | 150(9.8) | 1.36(1.09–1.69) | 0.007 |
Merged (Taiwan + Singapore + China) | ||||
CC | 1303(77.4) | 1314(79.8) | 1.00 | |
CT | 357(21.2) | 323(19.6) | 1.12(0.94–1.32) | 0.21 |
TT | 23(1.4) | 9(0.6) | 2.58(1.21–5.88) | 0.01 |
CT+TT | 380(22.6) | 332(20.0) | 1.15 (0.9–1.36) | 0.09 |
Common (C) allele | 2963(88.0) | 2951(89.6) | 1.00 | |
Minor (T) allele | 403(12.0) | 341(10.4) | 1.18(1.01–1.37) | 0.04 |
P-values and OR calculated in relation to CC genotype and a major allele C.
All p-values were calculated by means of chi-squared test.