Skip to main content
. 2013 Jun 24;8(6):e66816. doi: 10.1371/journal.pone.0066816

Figure 8. Analysis of global epigenetic modifications in several organs of mice fed either the CD or the HFD, born to either lean or obese/diabetic mothers (F1LM and F2OM).

Figure 8

(A) Global DNA methylation analysis by LUMA in the liver and muscle of CD, OR and OP females, HpaII/MspI levels indicate the degree of CCGG unmethylation. (B) Global analysis of posttranslational histone modifications by western blotting, for the liver of F2OM females. The values shown are the mean±SEM. a p<0.05 for comparison with control CD, b p<0.05 for comparison between OP and OR mice, c p<0.05 for comparison between the F1LM and F2OM mice born to lean and obese mothers, respectively, assessed by Kruskal-Wallis tests and post hoc Dunn’s tests.