Figure 4. Effect of caspase inhibitors on ECFC network formationin vitro .

ECFCs were tested un-treated (A) and upon eight hour pretreatment with either DMSO (B), Caspase-4 inhibitor Z-LEVD-FMK (C) or pan-caspase inhibitor Q-VD-OPh (D) in a 24 hour angiogenesis assay in vitro. Quantification of cell network branching points and corresponding un-paired t-test results (*** p≤0.0001) are depicted (E). Each field represents an area of 9.45 mm². Scale bar: 1000 µm, n = 3 per condition.