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. 2013 Jun 24;8(6):e66794. doi: 10.1371/journal.pone.0066794

Figure 1. Expression pattern of SMAD4 in OL and OSCC samples.

Figure 1

A, case 31: weak expression of SMAD4 in OL lesion which did not go through malignant transformation (x20). B, case 59:strong expression of SMAD4 in OL lesion which later went through malignant transformation (x20). C, OSCC samples which derived from OL lesion: weak expression of SMAD4 in OSCC samples. D, The frequency of strong SMAD4 expression is 39.4% in untransformed OL and 77.3% in malignant transformed OL. * indicated that p = 0.002.