Table 3. Associations between 87 SNPs in vitamin D-related genes and pancreas cancer risk among Ontario cases (n = 628) and controls (n = 1193) and age and sex adjusted OR using a log additive model.

Gene	SNP	Minor Allele	Major Allele	MAFa	HWE p-valueb	Age and Sex adjusted ORc	p-value	Adj p-valued
CASR	rs1042636	G	A	8.76	0.278	1.09	0.490	0.867
CASR	rs12485716	A	G	27.7	0.148	0.89	0.152	0.481
CASR	rs1354162	A	C	10.41	0.277	1.02	0.876	0.963
CASR	rs1501900	T	A	21.21	1.000	0.95	0.589	0.890
CASR	rs1801725	T	G	14.19	0.475	1.06	0.562	0.889
CASR	rs2134221	C	T	33.01	0.358	1.03	0.695	0.945
CASR	rs3804592	A	G	14.33	0.156	0.81	0.043	0.425
CASR	rs3845918	A	G	26.49	0.766	1.00	0.983	0.994
CASR	rs4678172	A	C	27.75	0.220	1.04	0.613	0.890
CASR	rs4678174	C	T	31.35	0.060	0.90	0.149	0.481
CASR	rs6438705	A	G	18.15	0.119	1.05	0.619	0.890
CASR	rs6762782	A	G	39.68	0.164	1.00	0.977	0.994
CASR	rs7432045	C	T	21.34	0.862	0.97	0.711	0.945
CUBN	rs1907362	A	G	3.91	1.000	1.16	0.399	0.789
CYP24A1	rs1570669	G	A	33.7	0.796	1.09	0.266	0.648
CYP24A1	rs2181874	A	G	24.98	0.354	1.12	0.148	0.481
CYP24A1	rs2209314	C	T	25.65	0.544	1.05	0.560	0.889
CYP24A1	rs2245153	C	T	18.83	0.924	0.98	0.782	0.963
CYP24A1	rs2248461	A	G	37.05	0.069	1.02	0.801	0.963
CYP24A1	rs2296241	G	A	47.32	0.202	1.07	0.336	0.731
CYP24A1	rs2426498	G	C	13.45	0.534	0.99	0.897	0.963
CYP24A1	rs2585428	A	G	46.55	0.449	0.91	0.154	0.481
CYP24A1	rs2762941	A	G	38.41	0.245	1.14	0.070	0.425
CYP24A1	rs4809955	G	A	13.55	0.804	1.16	0.145	0.481
CYP24A1	rs4809957	G	A	21.15	0.098	1.17	0.063	0.425
CYP24A1	rs4809958	G	T	15.17	0.071	1.23	0.026	0.425
CYP24A1	rs4809959	A	G	49.71	0.385	1.05	0.437	0.809
CYP24A1	rs6013897	A	T	20.79	1.000	1.02	0.788	0.963
CYP24A1	rs6013905	C	T	15.3	0.093	1.21	0.040	0.425
CYP24A1	rs6022999	G	A	23.65	0.810	0.95	0.504	0.867
CYP24A1	rs6097805	G	A	24.94	0.164	1.15	0.072	0.425
CYP24A1	rs6127119	T	C	22.2	0.179	1.20	0.027	0.425
CYP27B1	rs10877012	T	G	32.69	0.742	1.04	0.634	0.890
CYP27B1	rs4646536	C	T	33.11	0.744	1.07	0.360	0.764
CYP27B1	rs703842	C	T	33.18	0.696	1.06	0.399	0.789
CYP2R1	rs10741657	A	G	39.04	0.301	0.85	0.026	0.425
CYP2R1	rs11023374	C	T	27.21	0.002	1.16	0.050	0.425
CYP2R1	rs11819875	G	T	18.61	0.849	0.98	0.853	0.963
CYP2R1	rs12794714	A	G	43.08	0.140	1.16	0.031	0.425
CYP2R1	rs2060793	A	G	39.14	0.302	0.86	0.035	0.425
DHCR7	rs1630498	G	T	22.02	0.399	0.92	0.308	0.703
DHCR7	rs1790349	G	A	15.55	0.583	1.00	0.995	0.995
GC	rs1491711	C	G	34.42	0.083	1.11	0.138	0.481
GC	rs1491718	C	T	9.72	0.743	0.85	0.203	0.519
GC	rs2282679	C	A	26.85	0.555	1.01	0.882	0.963
GC	rs4588	A	C	26.91	0.508	1.00	0.953	0.994
GC	rs7041	T	G	43.76	0.445	1.02	0.782	0.963
LRP2	rs10210408	C	T	32.98	0.512	0.90	0.165	0.481
LRP2	rs11679947	A	G	49.66	1.000	1.12	0.114	0.481
LRP2	rs16856596	A	G	27.2	0.884	0.93	0.376	0.779
LRP2	rs2239598	C	T	33.46	0.134	1.10	0.185	0.519
LRP2	rs2241190	G	A	47.15	0.353	1.13	0.075	0.425
LRP2	rs2268373	C	G	24.92	0.643	1.16	0.057	0.425
LRP2	rs2544381	C	G	30.8	0.308	1.11	0.160	0.481
LRP2	rs3944004	G	T	21.88	0.091	1.23	0.011	0.425
LRP2	rs4668136	C	T	48.36	0.354	1.10	0.157	0.481
LRP2	rs830964	T	C	26.91	0.508	1.03	0.728	0.945
LRP2	rs831003	G	C	21.88	0.398	0.87	0.116	0.481
LRP2	rs990626	C	T	25.52	0.648	1.14	0.085	0.425
NADSYN1	rs3829251	A	G	15.67	0.513	1.07	0.493	0.867
NADSYN1	rs7944926	A	G	27.89	0.061	0.96	0.632	0.890
RXRA	rs12004589	T	G	12.49	0.426	0.89	0.292	0.687
RXRA	rs3118523	G	A	19.57	0.141	1.10	0.268	0.648
RXRA	rs3132299	G	C	18.61	0.389	1.01	0.887	0.963
RXRA	rs4842196	C	A	25.98	0.940	1.03	0.703	0.945
RXRA	rs7864987	C	T	25.55	0.148	1.05	0.508	0.867
RXRA	rs9409929	A	G	34.7	0.307	0.90	0.166	0.481
VDR	rs11168275	G	A	26.03	0.409	0.94	0.436	0.809
VDR	rs11568820	A	G	21.39	0.143	1.11	0.195	0.519
VDR	rs11574143	A	G	10.1	0.524	1.07	0.549	0.889
VDR	rs12721364	T	C	15.05	0.428	1.04	0.718	0.945
VDR	rs1544410	A	G	39.56	0.628	0.96	0.575	0.890
VDR	rs1989969	T	C	37.89	0.006	1.01	0.882	0.963
VDR	rs2107301	T	C	29.72	0.446	1.01	0.879	0.963
VDR	rs2189480	A	C	38.89	0.429	0.89	0.088	0.425
VDR	rs2228570	T	C	39.31	0.585	1.02	0.757	0.963
VDR	rs2238135	C	G	25.73	0.019	0.99	0.945	0.994
VDR	rs2238136	A	G	26.75	0.002	0.96	0.595	0.890
VDR	rs2239182	G	A	49.71	0.643	0.96	0.527	0.882
VDR	rs2283342	C	T	17.37	0.312	0.91	0.315	0.703
VDR	rs2853564	C	T	38.18	0.037	1.01	0.869	0.963
VDR	rs4237855	G	A	39.24	0.128	0.88	0.068	0.425
VDR	rs4334089	A	G	27.33	0.771	0.99	0.870	0.963
VDR	rs7299460	T	C	30.62	0.495	1.10	0.198	0.519
VDR	rs731236	C	T	39.01	0.429	0.95	0.428	0.809
VDR	rs7970314	G	A	23.11	0.142	1.15	0.087	0.425
VDR	rs7975232	C	A	47.35	0.684	1.00	0.979	0.994

^aMAF and HWE were calculated among controls only

^bFive SNPs (rs11023374, rs1989969, rs2238136, rs2238135, rs2853564) showed significant departure from HWE and were excluded from subsequent analyses

^cOdds ratios were estimated using logistic regression adjusted for age and sex and assuming a log additive model for each SNP.

^dAdjusted for multiple comparisons using the False Discovery Rate (FDR).