Table 2.
Neuropathology of TDP-43 positive cases.
| Case # | Location of Positivity | Inclusion Type | Age at death | ARG | WMR | iLB |
|---|---|---|---|---|---|---|
| 1 | Amygdale | DN | 75 | N | N | N |
| 2 | Amygdale | DN | 77 | Y | Y | N |
| 3 | parahippocampal gyrus | DN, NII | 78 | Y | Y | Y |
| 4 | amygdala | DN | 83 | N | N | Y |
| 5 | amygdala | DN | 84 | N | N | Y |
| 6 | parahippocampal gyrus | DN | 84 | N | N | N |
| 7 | hippocampus | DN | 85 | N | Y | N |
| 8 | amygdala | DN | 86 | Y | N | Y |
| 9 | amygdala | DN | 86 | Y | N | N |
| 10 | amygdala | DN | 87 | N | N | N |
| 11 | amygdala | DN | 87 | N | Y | N |
| 12 | subiculum | DN | 88 | N | Y | N |
| 13 | amygdala | DN | 88 | N | N | Y |
| 14 | parahippocampal gyrus /amygdala | DN, NCI | 90 | Y | Y | Y |
| 15 | parahippocampal gyrus | NCI | 90 | Y | N | N |
| 16 | amygdala | DN, NCI | 90 | Y | Y | N |
| 17 | amygdala | DN | 91 | N | N | N |
| 18 | parahippocampal gyrus and amygdala | DN, NCI | 91 | Y | Y | N |
| 19 | amygdala | DN, NCI | 91 | Y | Y | N |
| 20 | amygdala | DN, NCI | 91 | Y | Y | N |
| 21 | amygdala | DN | 91 | N | N | N |
| 22 | amygdala | DN | 91 | Y | N | N |
| 23 | subiculum / parahippocampal gyrus | DN | 92 | Y | N | Y |
| 24 | amygdala | DN | 92 | N | Y | Y |
| 25 | amygdala | DN | 94 | N | Y | Y |
| 26 | amygdala | DN | 97 | N | Y | N |
| 27* | amygdala | DN | 96 | N | N | N |
| 28* | subiculum / parahippocampal gyrus | DN | 98 | Y | N | N |
| 29* | subiculum / parahippocampal gyrus | DN | 73 | N | N | N |
| 30* | subiculum / parahippocampal gyrus | DN | 88 | N | N | N |
| 31* | amygdala | DN | 89 | N | Y | N |
| 32* | parahippocampal gyrus and amygdala | DN | 91 | N | N | N |
| 33* | amygdala | DN | 82 | Y | N | N |
| 34* | hippocampus | DN | 84 | N | N | N |
| 35* | subiculum / parahippocampal gyrus | DN | 96 | N | Y | N |
| 36* | parahippocampal gyrus and amygdala | DN | 88 | N | N | N |
| 37* | subiculum / parahippocampal gyrus | DN | 85 | N | N | N |
| 38* | subiculum / parahippocampal gyrus | DN | 90 | N | Y | N |
| 39* | amygdala | DN | 91 | Y | N | Y |
| 40* | amygdala | DN | 85 | Y | N | N |
DN = dystrophic neurites, NCI = neuronal cytoplasmic inclusions, NII = intranuclear inclusions, ARG = argyrophilic grains, WMR = white matter rarefaction, iLB = incidental Lewy bodies, Y = yes, N = no.
*
in cases 27–40 TDP-43 deposits were very rare, having less than 5 deposits in the entire 40μm section.