Table 2. The association between GSTP1 Ile105Val genotype and clinicopathological characteristics.
| Characteristics | Genotype of GSTP1
Ile105Val
|
|||
|---|---|---|---|---|
| Ile/Ile (%) | Ile/Val (%) | Val/Val (%) | Ile/Val and Val/Val (%) | |
| Age (year) | ||||
| >=55/<55 | 180 (54.1)/360 (61.3) | 129 (38.7)/196 (33.4) | 24 (7.2)/31 (5.3) | 153 (45.9)/227 (38.7) |
| OR (95% CI) | 1.00 | 1.32 (0.99-1.75) | 1.55 (0.88-2.72) | 1.35 (1.03-1.77) |
| P-value | 0.059 | 0.125 | 0.031 | |
| Histological grade | ||||
| III/I+II | 112 (51.6)/388 (64.1) | 103 (47.5)/202 (33.4) | 32 (14.7)/15 (2.5) | 105 (48.4)/217 (35.9) |
| OR (95% CI) | 1.00 | 1.17 (1.07-1.29) | 2.43 (1.60-3.70) | 1.15 (1.05-1.26) |
| P-value | 0.001 | < 0.001 | 0.001 | |
| Clinical stage | ||||
| III+IV/I+II | 92 (55.4)/447 (62.3) | 62 (37.3)/230 (32.1) | 12 (7.2)/40 (5.6) | 74 (44.6)/270 (37.6) |
| OR (95% CI) | 1.00 | 1.31 (0.92-1.88) | 1.46 (0.74-2.89) | 1.33 (0.95-1.87) |
| P-value | 0.140 | 0.277 | 0.099 | |
| Lymph node involvement | ||||
| Pos. / Neg. | 98 (44.7)/424 (65.5) | 99 (45.2)/193 (29.8) | 22 (10.0)/30 (4.6) | 121 (55.3)/223 (34.5) |
| OR (95% CI) | 1.00 | 2.22 (1.60-3.08) | 3.17 (1.76-5.74) | 2.35 (1.72-3.21) |
| P-value | 0.001 | < 0.001 | < 0.001 | |
| ER status | ||||
| Neg. / Pos. | 114 (46.0)/340 (60.1) | 104 (41.9)/206 (36.4) | 30 (12.1)/20 (3.5) | 134 (54.0)/226 (39.2) |
| OR (95% CI) | 1.00 | 1.51 (1.10-2.07) | 4.47 (2.45-8.19) | 1.77 (1.31-2.39) |
| P-value | 0.011 | < 0.001 | < 0.001 | |
| PR status | ||||
| Neg. / Pos. | 132 (57.1)/334 (57.3) | 83 (35.9)/225 (38.6) | 16 (6.9)/24 (4.1) | 99 (42.8)/249 (42.7) |
| OR (95% CI) | 1.00 | 0.93 (0.68-1.29) | 1.69 (0.87-3.28) | 1.01 (0.74-1.37) |
| P-value | 0.675 | 0.119 | 0.970 | |
| HER2 status | ||||
| Pos. / Neg. | 106 (56.4)/338 (54.0) | 68 (36.2)/252 (40.3) | 14 (7.4)/36 (5.8) | 82 (43.6)/288 (46.0) |
| OR (95% CI) | 1.00 | 0.86 (0.61-1.22) | 1.24 (0.64-2.39) | 0.91 (0.65-1.26) |
| P-value | 0.394 | 0.519 | 0.564 | |