Table 4. Gene expression of selected genes in liver of rats after 50 weeks of diet administration1.
Dietary supplementation2 | Statistical significance of variance ratio (P)3, effects of | ||||||
Control | TTA | FO | TTA+FO | TTA | FO | TTA*FO | |
Aldh9a1 | 1.00±0.20 | 1.31±0.18 | 1.02±0.61 | 1.11±0.16 | 0.07 | 0.40 | 0.31 |
Bbox1 | 1.00±0.27 | 1.13±0.21 | 0.86±0.27 | 1.05±0.26 | 0.05 | 0.18 | 0.65 |
Tmlhe | 1.00±0.22 | 1.15±0.13 | 0.98±0.26 | 1.02±0.13 | 0.15 | 0.26 | 0.34 |
Aox3 | 1.00±0.22 | 0.31±0.16 | 0.83±0.47 | 0.33±0.15 | <0.001 | 0.38 | 0.30 |
Clpx | 1.00±0.33 | 2.76±0.87 | 1.48±0.42 | 2.81±0.73 | <0.001 | 0.20 | 0.29 |
Cyp7b1 | 1.00±0.31 | 0.97±0.34 | 0.93±0.34 | 0.69±0.14 | 0.17 | 0.11 | 0.28 |
Aadat | 1.00±0.20 | 1.41±0.23 | 0.96±0.25 | 1.45±0.36 | <0.001 | 0.98 | 0.65 |
Glyctk | 1.00±0.19 | 1.21±0.19 | 0.98±0.22 | 1.04±0.11 | 0.03 | 0.10 | 0.17 |
Cbs | 1.00±0.31 | 1.03±0.38 | 0.78±0.24 | 1.16±0.21 | 0.03 | 0.66 | 0.07 |
Shmt2 | 1.00±0.31 | 1.31±0.38 | 0.84±0.22 | 1.19±0.44 | 0.005 | 0.19 | 0.85 |
Hdc | 1.00±0.70 | 57.83±20.87 | 10.43±3.91 | 71.74±30.43 | <0.001 | 0.05 | 0.69 |
Glul | 1.00±0.43 | 1.03±0.34 | 0.90±0.26 | 1.12±0.38 | 0.28 | 0.93 | 0.38 |
Glud1 | 1.00±0.27 | 1.57±0.28 | 0.94±0.37 | 1.40±0.34 | <0.001 | 0.24 | 0.60 |
Arg1 | 1.00±0.38 | 0.86±0.23 | 0.58±0.17 | 0.69±0.23 | 0.88 | 0.001 | 0.13 |
Ass1 | 1.00±0.43 | 0.41±0.19 | 0.57±0.39 | 0.44±0.16 | 0.001 | 0.06 | 0.03 |
Asl | 1.00±0.28 | 0.59±0.15 | 0.78±0.24 | 0.61±0.10 | <0.001 | 0.11 | 0.07 |
Abbreviations: TTA, tetradecylthioacetic acid; FO, fish oil; Aldh9a1, aldehyde dehydrogenase 9, subfamily A1; Bbox1, gamma-butyrobetaine hydroxylase 1; Tmlhe, trimethyllysine hydroxylase, epsilon; Aox3, aldehyde oxidase 3; Clpx, ClpX caseinolytic peptidase×homolog; Cyp7b1, cytochrome P450, family 7, subfamily B, polypeptide 1; Aadat, aminoadipate aminotransferase; Glyctk, glycerate kinase; Cbs, cystathionine beta synthase; Shmt2, serine hydroxymethyltransferase; Hdc, histidine decarboxylase; Glul, glutamate-ammonia ligase; Glud1, glutamate dehydrogenase 1; Arg1, arginase, liver; Ass1, argininosuccinate synthase 1; Asl, argininosuccinate lyase.
Relative to control diet.
Values are mean ± SD (n = 10).
P-values from two-way ANOVA.