In all experiments, WT MOG- and OVA-specific CD8 T-cells were transferred i.v. into WT B6 mice. Additional groups received MOG-specific CD8 T-cells derived from IFN-γ−/− (A), perforin−/− (B), IFN-γR−/− (C), IL10−/− (D) or IL4−/− (E) mice. The next day, EAE was induced in all groups by MOG35–55/CFA immunization. Clinical scores are shown. Each graph is representative of two independent experimental replicates (n=14 per condition).