Representative MR images of the eyes of a 3-month-old WT, 1- and 3-month-old rd1 mice at baseline and T1W signal enhancement in the same eyes at 10, 20, and 30 min after intraperitoneal injection of Gd-DTPA (a–c). Quantitative analysis shows that the vitreous signal in 3-month-old rd1 mice increases monotonically after Gd-DTPA injection and is ~40% higher than the baseline value at 30 min (d). In contrast, only around 10% vitreous signal enhancement was observed in 1-month-old rd1 mice and all WT mice. *, P < 0.05 compared with 1-month-old rd1 mice and all WT mice at 10 min; **, P < 0.005 compared with 1-month-old rd1 mice and all WT mice at 20 min and all time points after that.