Table III.

Comparison of Pharmacokinetic Parameters Between Promptol™ Tablet 10 mg and Inderal^® Tablet 10 mg

PK parameters	Promptol™ tablet (10 mg, test)	Inderal® tablet (10 mg, reference)	p value
T max (min)	102 ± 67	107 ± 33	0.772
C max (ng/ml)	15.5 ± 5.6	8.6 ± 5.8	0.000
AUC0–last (μg min/ml)	4.60 ± 1.66	1.95 ± 1.40	0.000
AUC0–∞ (μg min/ml)	5.36 ± 2.04	2.26 ± 1.65	0.000
T 1/2 (min)	184 ± 38	171 ± 55	0.336
Relative F (%)	300 ± 127	N/A	N/A

T _max time to peak drug concentration, C _max peak drug concentration, AUC _0–last area under the concentration–time curve from time zero to the last sampling time t obtained by trapezoidal rule, AUC _0–∞ area under the concentration–time curve from time zero to infinity, T _1/2 terminal elimination half-life, F relative bioavailability for the sublingual Promptol™ tablet to oral Inderal^® tablet, N/A not applicable