Table I.
Pharmacokinetic Parameters of δ-T3 and γ-T3 Following i.v. Administration of 10 mg/kg, and 1 mg/ml, Respectively (n = 4)
| Pharmacokinetic parameter | δ-T3 | γ-T3 |
|---|---|---|
| AUC, μg h/ml | 29.3 ± 2.4 | 5.7 ± 0.6 |
| MRT, h | 1.1 ± 0.3 | 1.1 ± 0.1 |
| V c, l/kg | 0.08 ± 0.01 | 0.5 ± 0.1 |
| V 2, l/kg | 0.2 ± 0.01 | 0.95 ± 0.01 |
| CL, l/h/kg | 0.4 ± 0.04 | 1.9 ± 0.2 |
| T 1/2, h | 3 ± 0.3 | 2.3 ± 0.1 |
Each value represents the mean ± SD
MRT mean residence time, V c central compartment volume of distribution, V 2 peripheral compartment volume of distribution, CL systemic clearance