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. 2013 Jul;142(1):75–85. doi: 10.1085/jgp.201310985

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© 2013 Rowe et al.

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Figure 6. — Effects of trehalose on MscS-like and MscL-like channel activation. Trehalose induces substantial left-shift of activation curves, which is more pronounced for MscL in V. cholerae (A) than in E. coli (B). The three curves represent trehalose concentrations of 0 (black), 0.5 (blue), and 1.0 M (red). Magnified early responses in V. cholerae (C) and E. coli (D) specifically show the right-shift of the MscS curve as well as reduced single-channel conductance in response to 1 M trehalose.